Integrative Virology

Welcome to the Topf Lab !

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Our research focuses on developing integrative structural methods that combine experimental data, bioinformatics, and modeling techniques to elucidate the structures of macromolecular assemblies in viruses and their interactions with host cells. These structural models provide critical insights that guide experimental design and the development of potential inhibitors.

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We are particularly interested in leveraging data from cryoEM, cryoET, and mass spectrometry to study viral assemblies. Through close collaborations with experimentalists, we aim to characterize key macromolecular complexes across various virus families, including herpesviruses and arenaviruses, to deepen our understanding of their structure and function.